@article{6ba0fc5d231847218cd567841bcb5578,
title = "HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging",
abstract = "We investigated the interactions between human immunodeficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected subjects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interaction occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15-20 years older. Frailty parallels between HIV infection and aging could result from continued immunological challenges depleting resources and triggering increased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain.",
author = "Ances, {Beau M.} and Florin Vaida and Yeh, {Melinda J.} and Liang, {Christine L.} and Buxton, {Richard B.} and Scott Letendre and {Allen McCutchan}, J. and Ellis, {Ronald J.}",
note = "Funding Information: Received 30 April 2009; accepted 6 August 2009; electronically published 4 January 2010. Potential conflicts of interest: none reported. Presented in part: 16th Conference on Retrovirus and Opportunistic Infections, Montreal, Canada, 8–11 February 2009 (abstract 157). Financial support: Dana Foundation (Brain Immuno Imaging Award DF3857-41880 to B.A.); National Institutes of Health (grant 1K23MH081786 to B.A.; grants NS-36722 and NS-42069 to R.B. and C.L.; grant P30 MH62512 to the HIV Neurobehavioral Research Center; grants AI36214, AI29164, AI47745, AI57167, AI55276, and MH62512 to A.M. and S.L.; grants MH22005 and AI47033 to F.V.; and grants AI27670 and AI43638 to R.E.); University of California, San Diego Center for AIDS Research. Reprints or correspondence: Dr Beau M. Ances, Dept of Neurology, Washington University in St Louis, 660 S Euclid Ave, Box 81111, St Louis, MO 63110 (bances@wustl.edu).",
year = "2010",
month = feb,
day = "1",
doi = "10.1086/649899",
language = "English",
volume = "201",
pages = "336--340",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
number = "3",
}