TY - JOUR
T1 - HIV-associated neuromuscular weakness syndrome in Brazil
T2 - Report of the two first cases
AU - Vidal, José E.
AU - Clifford, David
AU - Ferreira, Cláudio Meilman
AU - Penalva De Oliveira, Augusto C.
PY - 2007/9
Y1 - 2007/9
N2 - We describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.
AB - We describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.
KW - Antiretroviral agents
KW - Human immunodeficiency virus
KW - Neuromuscular diseases
KW - Peripheral neuropathies
UR - http://www.scopus.com/inward/record.url?scp=35448989646&partnerID=8YFLogxK
U2 - 10.1590/S0004-282X2007000500024
DO - 10.1590/S0004-282X2007000500024
M3 - Article
C2 - 17952295
AN - SCOPUS:35448989646
SN - 0004-282X
VL - 65
SP - 848
EP - 851
JO - Arquivos de Neuro-Psiquiatria
JF - Arquivos de Neuro-Psiquiatria
IS - 3 B
ER -