@article{f1956ce0cb8346a99a83403f4087990f,
title = "HIV-1 DNA is detected in bone marrow populations containing CD4 + T cells but is not found in purified CD34 + hematopoietic progenitor cells in most patients on antiretroviral therapy",
abstract = "Identifying cellular reservoirs of human immunodeficiency virus type 1 (HIV-1) in patients on antiretroviral therapy (ART) is critical to finding a cure for HIV-1. In addition to resting CD4 + T cells, CD34 + hematopoietic progenitor cells have been proposed as another reservoir. We obtained bone marrow aspirates from 11 patients on ART who had undetectable plasma HIV-1 RNA. HIV-1 DNA was detected in CD4 + T cells from peripheral blood in all patients and from bone marrow cellular fractions containing T cells in most patients. We did not find HIV-1 DNA in highly purified CD34 + populations using either a sensitive real-time polymerase chain reaction assay or a coculture assay for replication-competent HIV-1.",
author = "Durand, {Christine M.} and Gabriel Ghiaur and Siliciano, {Janet D.} and Rabi, {S. Alireza} and Eisele, {Evelyn E.} and Maria Salgado and Liang Shan and Lai, {Jun F.} and Hao Zhang and Joseph Margolick and Jones, {Richard J.} and Gallant, {Joel E.} and Ambinder, {Richard F.} and Siliciano, {Robert F.}",
note = "Funding Information: Financial support. This work was supported by the National Institutes of Health (NIH), National Cancer Institute (grants P30CA06973 and P01CA1539627); Howard Hughes Medical Institute and NIH; and National Institute of Allergy and Infectious Diseases (grant AI43222 to R. F. S). Potential conflicts of interest. All authors: No reported conflicts.",
year = "2012",
month = mar,
day = "15",
doi = "10.1093/infdis/jir884",
language = "English",
volume = "205",
pages = "1014--1018",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
number = "6",
}