History of prostate-specific antigen, from detection to overdiagnosis

Brandon J. Manley, Gerald L. Andriole

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

The history of prostate-specific antigen (PSA) is full of significant discoveries that have revolutionized the diagnosis and management of prostate cancer. In this chapter we summarize the history of the discovery of PSA and how it became such an integral part of prostate cancer management. Basic biology and physiology of PSA will also be discussed to provide insight about its current and future applications. The use of PSA to screen for prostate cancer remains a controversial topic of debate and in this chapter we present some of the salient points in the arguments for and against the use of PSA screening. This chapter provides a focused literature review of the benefits and risks of PSA screening and a basis for its current recommendations for prostate cancer early detection.

Original languageEnglish
Title of host publicationThe Prostate Cancer Dilemma
Subtitle of host publicationSelecting Patients for Active Surveillance, Focal Ablation and Definitive Therapy
PublisherSpringer International Publishing
Pages3-16
Number of pages14
ISBN (Electronic)9783319214856
ISBN (Print)9783319214849
DOIs
StatePublished - Jan 1 2016

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