TY - JOUR
T1 - History of obstructive sleep apnea associated with incident cognitive impairment in white but not black individuals in a US national cohort study
AU - Sawyer, Russell P.
AU - Bennett, Aleena
AU - Blair, Jessica
AU - Molano, Jennifer
AU - Timmerman, Emerlee
AU - Foster, Forrest
AU - Karkoska, Kristine
AU - Hyacinth, Hyacinth I.
AU - Manly, Jennifer J.
AU - Howard, Virginia J.
AU - Petrov, Megan E.
AU - Hoffmann, Coles M.
AU - Yu, Fang
AU - Demel, Stacie L.
AU - Aziz, Yasmin
AU - Hooper, Destiny
AU - Hill, Emily J.
AU - Johnson, Jamelle
AU - Pounders, Johnson
AU - Shatz, Rhonna
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/12
Y1 - 2023/12
N2 - Background: We sought to determine if risk for obstructive sleep apnea (OSA), a history of OSA, and/or treatment of OSA has a different association with incident cognitive impairment or cognitive decline in Black individuals and White individuals. Methods: To determine whether the risk for OSA, a history of OSA, and/or treatment of OSA has a different association with incident cognitive impairment or cognitive decline in Black individuals and White individuals; data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) was used. Participants that completed the sleep questionnaire module, had baseline cognitive assessment, and at least one cognitive assessment during follow-up were included. Risk of OSA was determined based on Berlin Sleep Questionnaire. History of sleep apnea was determined based on structured interview questions. Optimally treated OSA was defined as treated sleep apnea as at least 4 h of continuous positive airway pressure use per night for ≥5 nights per week. Results: In 19,017 participants stratified by race, White participants with history of OSA were 1.62 times more likely to have incident cognitive impairment compared to White participants without history of OSA after adjusting for demographic characteristics, history, and lifestyle factors (OR = 1.62, 95% CI = 1.05–2.50, p-value = 0.03). This relationship was not seen in Black participants (OR = 0.92, 95% CI = 0.60–1.43, p-value = 0.72). Discussion: A previous diagnosis of OSA is associated with incident cognitive impairment in White Americans but not Black Americans. Further investigations are required to determine the mechanism for this difference.
AB - Background: We sought to determine if risk for obstructive sleep apnea (OSA), a history of OSA, and/or treatment of OSA has a different association with incident cognitive impairment or cognitive decline in Black individuals and White individuals. Methods: To determine whether the risk for OSA, a history of OSA, and/or treatment of OSA has a different association with incident cognitive impairment or cognitive decline in Black individuals and White individuals; data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) was used. Participants that completed the sleep questionnaire module, had baseline cognitive assessment, and at least one cognitive assessment during follow-up were included. Risk of OSA was determined based on Berlin Sleep Questionnaire. History of sleep apnea was determined based on structured interview questions. Optimally treated OSA was defined as treated sleep apnea as at least 4 h of continuous positive airway pressure use per night for ≥5 nights per week. Results: In 19,017 participants stratified by race, White participants with history of OSA were 1.62 times more likely to have incident cognitive impairment compared to White participants without history of OSA after adjusting for demographic characteristics, history, and lifestyle factors (OR = 1.62, 95% CI = 1.05–2.50, p-value = 0.03). This relationship was not seen in Black participants (OR = 0.92, 95% CI = 0.60–1.43, p-value = 0.72). Discussion: A previous diagnosis of OSA is associated with incident cognitive impairment in White Americans but not Black Americans. Further investigations are required to determine the mechanism for this difference.
KW - Cognitive impairment
KW - Obstructive sleep apnea
KW - Racial disparities
UR - http://www.scopus.com/inward/record.url?scp=85172868109&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2023.09.021
DO - 10.1016/j.sleep.2023.09.021
M3 - Article
C2 - 37801859
AN - SCOPUS:85172868109
SN - 1389-9457
VL - 112
SP - 1
EP - 8
JO - Sleep Medicine
JF - Sleep Medicine
ER -