Historical overview of chemical library design.

Roland E. Dolle

doi:10.1007/978-1-60761-931-4_1

Historical overview of chemical library design.

Roland E. Dolle

Research output: Contribution to journal › Review article

21 Scopus citations

Abstract

High-throughput chemistry (HTC) is approaching its 20-year anniversary. Since 1992, some 5,000 chemical libraries, prepared for the purpose of biological investigation and drug discovery, have been published in the scientific literature. This review highlights the key events in the history of HTC with emphasis on library design. A historical perspective on the design of screening, targeted, and optimization libraries and their application is presented. Design strategies pioneered in the 1990s remain viable in the twenty-first century.

Original language	English
Pages (from-to)	3-25
Number of pages	23
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	685
DOIs	https://doi.org/10.1007/978-1-60761-931-4_1
State	Published - 2011
Externally published	Yes

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10.1007/978-1-60761-931-4_1

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Dolle, R. E. (2011). Historical overview of chemical library design. Methods in molecular biology (Clifton, N.J.), 685, 3-25. https://doi.org/10.1007/978-1-60761-931-4_1

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