TY - JOUR
T1 - Historical overview of chemical library design.
AU - Dolle, Roland E.
PY - 2011
Y1 - 2011
N2 - High-throughput chemistry (HTC) is approaching its 20-year anniversary. Since 1992, some 5,000 chemical libraries, prepared for the purpose of biological investigation and drug discovery, have been published in the scientific literature. This review highlights the key events in the history of HTC with emphasis on library design. A historical perspective on the design of screening, targeted, and optimization libraries and their application is presented. Design strategies pioneered in the 1990s remain viable in the twenty-first century.
AB - High-throughput chemistry (HTC) is approaching its 20-year anniversary. Since 1992, some 5,000 chemical libraries, prepared for the purpose of biological investigation and drug discovery, have been published in the scientific literature. This review highlights the key events in the history of HTC with emphasis on library design. A historical perspective on the design of screening, targeted, and optimization libraries and their application is presented. Design strategies pioneered in the 1990s remain viable in the twenty-first century.
UR - http://www.scopus.com/inward/record.url?scp=79952198295&partnerID=8YFLogxK
U2 - 10.1007/978-1-60761-931-4_1
DO - 10.1007/978-1-60761-931-4_1
M3 - Review article
C2 - 20981516
AN - SCOPUS:79952198295
VL - 685
SP - 3
EP - 25
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
SN - 1064-3745
ER -