Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

Mai He; Priya Skaria; Kasey Kreutz; Ling Chen; Ian S. Hagemann; Ebony B. Carter; Indira U. Mysorekar; D  Michael Nelson; John Pfeifer; Louis P. Dehner

doi:10.1080/15513815.2020.1828517

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

Mai He, Priya Skaria, Kasey Kreutz, Ling Chen, Ian S. Hagemann, Ebony B. Carter, Indira U. Mysorekar, D Michael Nelson, John Pfeifer, Louis P. Dehner

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: This study aims to investigate whether maternal SARS-CoV-2 status affects placental pathology. Methods: A retrospective case-control study was conducted by reviewing charts and slides of placentas delivered between April 1 to July 24, 2020. Clinical history of “COVID-19” was searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3^rd-trimester. Pathological features were extracted from placental pathology reports. Results: Twenty-one 3^rd trimester placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women. Conclusion: Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3^rd trimester does not have a demonstrable effect on placental structure and pathology.

Original language	English
Pages (from-to)	403-412
Number of pages	10
Journal	Fetal and Pediatric Pathology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1080/15513815.2020.1828517
State	Published - 2022

Keywords

COVID-19
pathology
placenta
third trimester

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10.1080/15513815.2020.1828517

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title = "Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women",

abstract = "Background: This study aims to investigate whether maternal SARS-CoV-2 status affects placental pathology. Methods: A retrospective case-control study was conducted by reviewing charts and slides of placentas delivered between April 1 to July 24, 2020. Clinical history of “COVID-19” was searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3rd-trimester. Pathological features were extracted from placental pathology reports. Results: Twenty-one 3rd trimester placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women. Conclusion: Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3rd trimester does not have a demonstrable effect on placental structure and pathology.",

keywords = "COVID-19, pathology, placenta, third trimester",

author = "Mai He and Priya Skaria and Kasey Kreutz and Ling Chen and Hagemann, {Ian S.} and Carter, {Ebony B.} and Mysorekar, {Indira U.} and Nelson, {D Michael} and John Pfeifer and Dehner, {Louis P.}",

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year = "2022",

doi = "10.1080/15513815.2020.1828517",

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AU - He, Mai

AU - Skaria, Priya

AU - Kreutz, Kasey

AU - Chen, Ling

AU - Hagemann, Ian S.

AU - Carter, Ebony B.

AU - Mysorekar, Indira U.

AU - Nelson, D Michael

AU - Pfeifer, John

AU - Dehner, Louis P.

PY - 2022

Y1 - 2022

N2 - Background: This study aims to investigate whether maternal SARS-CoV-2 status affects placental pathology. Methods: A retrospective case-control study was conducted by reviewing charts and slides of placentas delivered between April 1 to July 24, 2020. Clinical history of “COVID-19” was searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3rd-trimester. Pathological features were extracted from placental pathology reports. Results: Twenty-one 3rd trimester placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women. Conclusion: Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3rd trimester does not have a demonstrable effect on placental structure and pathology.

AB - Background: This study aims to investigate whether maternal SARS-CoV-2 status affects placental pathology. Methods: A retrospective case-control study was conducted by reviewing charts and slides of placentas delivered between April 1 to July 24, 2020. Clinical history of “COVID-19” was searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3rd-trimester. Pathological features were extracted from placental pathology reports. Results: Twenty-one 3rd trimester placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women. Conclusion: Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3rd trimester does not have a demonstrable effect on placental structure and pathology.

KW - COVID-19

KW - pathology

KW - placenta

KW - third trimester

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JO - Fetal and Pediatric Pathology

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IS - 3

ER -

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

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Keywords

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