TY - JOUR
T1 - Histopathology of nonalcoholic fatty liver disease
AU - Brunt, Elizabeth M.
AU - Tiniakos, Dina G.
PY - 2010/11/14
Y1 - 2010/11/14
N2 - Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed.
AB - Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed.
KW - Fatty liver
KW - Fibrosis
KW - Nonalcoholic fatty liver disease
KW - Nonalcoholic steatohepatitis
KW - Steatosis
UR - http://www.scopus.com/inward/record.url?scp=78649433367&partnerID=8YFLogxK
U2 - 10.3748/wjg.v16.i42.5286
DO - 10.3748/wjg.v16.i42.5286
M3 - Review article
C2 - 21072891
AN - SCOPUS:78649433367
VL - 16
SP - 5286
EP - 5296
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 42
ER -