Histopathology of nonalcoholic fatty liver disease

Elizabeth M. Brunt, Dina G. Tiniakos

Research output: Contribution to journalReview article

221 Scopus citations

Abstract

Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed.

Original languageEnglish
Pages (from-to)5286-5296
Number of pages11
JournalWorld Journal of Gastroenterology
Volume16
Issue number42
DOIs
StatePublished - Nov 14 2010

Keywords

  • Fatty liver
  • Fibrosis
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Steatosis

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