Histopathology of Non-Alcoholic Fatty Liver Disease

Elizabeth M. Brunt

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

Current imaging methodologies can detect steatosis with increasing accuracy but cannot detect inflammation or pre-cirrhotic fibrosis or remodeling of the liver parenchyma. Imaging also cannot assess types or localization of hepatic steatosis. With the increased use of rodents to study NAFLD/NASH, careful analysis or reading highlights the fact that liver tissue evaluations reported in many of the popular animal models of NAFLD/NASH often do not imitate many of the significant aspects of the human disease, despite similar terminology applied by investigators. This review will focus on the findings in human disease.

Original languageEnglish
Pages (from-to)533-544
Number of pages12
JournalClinics in Liver Disease
Volume13
Issue number4
DOIs
StatePublished - Nov 2009

Keywords

  • Histologic lesions
  • NASH
  • Steatosis

Fingerprint

Dive into the research topics of 'Histopathology of Non-Alcoholic Fatty Liver Disease'. Together they form a unique fingerprint.

Cite this