Histopathological features of the terminal ileum in lymphocytic and collagenous colitis: A study of 32 cases and review of literature

Vijayalakshmi Padmanabhan, Peter W. Callas, Shuan C. Li, Thomas D. Trainer

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Biopsy specimens from the terminal ileum of 32 patients with the histopathological diagnosis of lymphocytic colitis or collagenous colitis and 11 control individuals were evaluated for the presence or absence of ileal mucosal abnormalities and for the number of intraepithelial lymphocytes, assessed by immunohistochemical stains for the pan T-cell marker, CD3. We found that the mean CD3 counts in patients with lymphocytic/collagenous colitis were significantly higher than those in the control group. Seven of 14 patients with collagenous colitis and 14 of 18 patients with lymphocytic colitis revealed an increase in intraepithelial T lymphocytes when compared with the control group (P = .001). Other notable changes included ileal villous atrophy in one case of lymphocytic colitis and in three cases of collagenous colitis and epithelial damage with thickened subepithelial collagen in two cases of collagenous colitis.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalModern Pathology
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Collagenous colitis
  • Ileal villous atrophy
  • Lymphocytic colitis
  • Terminal ileum

Fingerprint

Dive into the research topics of 'Histopathological features of the terminal ileum in lymphocytic and collagenous colitis: A study of 32 cases and review of literature'. Together they form a unique fingerprint.

Cite this