Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival

Calixto Hope G. Lucas, Harish N. Vasudevan, William C. Chen, Stephen T. Magill, Steve E. Braunstein, Line Jacques, Sonika Dahiya, Fausto J. Rodriguez, Andrew E. Horvai, Arie Perry, Melike Pekmezci, David R. Raleigh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive and poorly understood malignant neoplasm. Even in the setting of multimodal therapy, the clinical course of MPNST is frequently marked by metastatic conversion and poor overall prognosis, with optimal treatment paradigms for this rare tumor unknown. Methods: We reviewed the medical records and histopathology of 54 consecutive patients who were treated at University of California San Francisco between 1990 and 2018. Results: Our cohort consisted of 24 male and 30 female patients (median age 38 years). FCrossed D sign

Original languageEnglish
Article numbervdaa131
JournalNeuro-Oncology Advances
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • clinical outcomes
  • FCrossed D sign©dCrossed D sign©ration Nationale des Centres de Lutte Contre Le Cancer
  • immunohistochemistry
  • malignant peripheral nerve sheath tumor
  • radiotherapy

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