TY - JOUR
T1 - Histone demethylase JMJD1A promotes tumor progression via activating snail in prostate cancer
AU - Tang, Dong E.
AU - Dai, Yong
AU - Fan, Ling Ling
AU - Geng, Xin Yan
AU - Fu, De Xue
AU - Jiang, Hao Wu
AU - Xu, Song Hui
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (31700795), the Science & Technology Planning Project of Guangdong Province of China (2017B020209001), the Natural Science Foundation of Guangdong Province of China (2017A030310629), and the Science & Technology Plan of Shenzhen (JCYJ20170307095606266).
Publisher Copyright:
© 2020 American Association for Cancer Research.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - The histone demethylase JMJD1A plays a key functional role in spermatogenesis, sex determination, stem cell renewal, and cancer via removing mono- and di-methyl groups from H3K9 to epigenetically control gene expression. However, its role in prostate cancer progression remains unclear. Here, we found JMJD1A was significantly elevated in prostate cancer tissue compared with matched normal tissue. Ectopic JMJD1A expression in prostate cancer cells promoted proliferation, migration, and invasion in vitro, and tumorigenesis in vivo; JMJD1A knockdown exhibited the opposite effects. Mechanically, we revealed that JMJD1A directly interacted with the Snail gene promoter and regulated its transcriptional activity, promoting prostate cancer progression both in vitro and in vivo. Furthermore, we found that JMJD1A transcriptionally activated Snail expression via H3K9me1 and H3K9me2 demethylation at its special promoter region. In summary, our studies reveal JMJD1A plays an important role in regulating proliferation and progression of prostate cancer cells though Snail, and thus highlight JMJD1A as potential therapeutic target for advanced prostate cancer.
AB - The histone demethylase JMJD1A plays a key functional role in spermatogenesis, sex determination, stem cell renewal, and cancer via removing mono- and di-methyl groups from H3K9 to epigenetically control gene expression. However, its role in prostate cancer progression remains unclear. Here, we found JMJD1A was significantly elevated in prostate cancer tissue compared with matched normal tissue. Ectopic JMJD1A expression in prostate cancer cells promoted proliferation, migration, and invasion in vitro, and tumorigenesis in vivo; JMJD1A knockdown exhibited the opposite effects. Mechanically, we revealed that JMJD1A directly interacted with the Snail gene promoter and regulated its transcriptional activity, promoting prostate cancer progression both in vitro and in vivo. Furthermore, we found that JMJD1A transcriptionally activated Snail expression via H3K9me1 and H3K9me2 demethylation at its special promoter region. In summary, our studies reveal JMJD1A plays an important role in regulating proliferation and progression of prostate cancer cells though Snail, and thus highlight JMJD1A as potential therapeutic target for advanced prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=85084961065&partnerID=8YFLogxK
U2 - 10.1158/1541-7786.MCR-19-0889
DO - 10.1158/1541-7786.MCR-19-0889
M3 - Article
C2 - 32019811
AN - SCOPUS:85084961065
SN - 1541-7786
VL - 18
SP - 698
EP - 708
JO - Molecular Cancer Research
JF - Molecular Cancer Research
IS - 5
ER -