Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation

Keyphrases

• Histone Deacetylase Inhibitor (HDACi) 100%
• Ionizing Radiation 100%
• Cytotoxic Effect 100%
• Human Non-small Cell Lung Cancer 100%
• LAQ824 100%
• Irradiation 30%
• Tumor Growth 20%
• Non-small Cell Lung Cancer (NSCLC) 20%
• Radiation Effects 20%
• Immunostaining 10%
• Disease Progression 10%
• Mouse Model 10%
• Apoptosis 10%
• DNA Repair 10%
• Radiation Therapy 10%
• Propidium Iodide 10%
• Clonogenic Survival 10%
• Mitosis 10%
• Combination Chemotherapy 10%
• Western Blot Analysis 10%
• Stage III Non-small Cell Lung Cancer 10%
• Human Lung Cancer 10%
• Combined Modality Therapy 10%
• Failure Pattern 10%
• Microscopic Analysis 10%
• Fluorescein Isothiocyanate 10%
• DNA Double-strand Breaks 10%
• Annexin 10%
• Cell Staining 10%
• Nuclear Foci 10%
• Caspase Cleavage 10%
• Radiation-induced Apoptosis 10%
• Flow Cytometry Assay 10%
• Primary Pattern 10%
• γH2AX Foci 10%
• H2AX 10%
• Colony Formation Assay 10%
• In Vivo Xenograft Model 10%
• H460 Cells 10%

Medicine and Dentistry

• Non Small Cell Lung Cancer 100%
• Histone Deacetylase Inhibitor 100%
• Ionizing Radiation 100%
• Cytotoxicity 100%
• Dacinostat 100%
• Programmed Cell Death 20%
• Tumor Progression 20%
• Immunohistochemistry 10%
• Lung Cancer 10%
• Flow Cytometry 10%
• Cell Line 10%
• Propidium Iodide 10%
• DNA Repair 10%
• Western Blot 10%
• Xenograft 10%
• Colony Formation 10%
• Fluorescein Isothiocyanate 10%
• Caspase 10%
• Lipocortin 10%
• Diseases 10%
• Radiation Therapy 10%
• Double-Strand DNA Break 10%
• Treatment Modality 10%