Histologic assessment of nerve regeneration in the rat

Susan E. MacKinnon, Alan R. Hudson, Daniel A. Hunter

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

This study reports the degree of spontaneous regeneration that will occur in the sciatic nerve of a rat 5 months after complete resection of the nerve. In 30 animals, the sciatic nerve was excised. Histological assessment at 5 months revealed evidence of regeneration for a variable distance (mean 23.7 mm ± 6.4 mm). Histological sections were studied at 1-cm intervals along the length of the nerve. Evidence of compartrnentation with “minifascicle” formation was noted. The orientation of the nerve fibers was parallel to the long axis of the nerve. This study assessing spontaneous regeneration is meant to serve as a control for other studies evaluating the effect of factors that may influence nerve regeneration in the rat model.

Original languageEnglish
Pages (from-to)384-388
Number of pages5
JournalPlastic and reconstructive surgery
Volume75
Issue number3
DOIs
StatePublished - Mar 1985

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