TY - JOUR
T1 - Histologic and immunohistochemical features of an epiretinal membrane overlying a combined hamartoma of the retina and retinal pigment epithelium
AU - Almony, Arghavan
AU - Blinder, Kevin J.
AU - Harocopos, George J.
AU - Shah, Gaurav K.
AU - Rao, P. Kumar
AU - Smith, Morton E.
AU - Dintzis, Suzanne M.
AU - VanGelder, Russell N.
PY - 2010
Y1 - 2010
N2 - Purpose: To present the histologic and immunohistochemical findings of an epiretinal membrane overlying a combined hamartoma of the retina and retinal pigment epithelium. Methods: An interventional case report. Results: A 17-year-old healthy girl with a history of congenital cataract presented with a combined hamartoma of the retina and retinal pigment epithelium with prominent epiretinal membrane portion. Pars plana vitrectomy and membranectomy were performed, and the excised epiretinal membrane was submitted for routine histology and immunohistochemistry. Hematoxylin and eosin stain showed a monolayer of cells with an underlying basement membrane. Some of the nuclei were more epithelioid, consistent with retinal pigment epithelium (but without pigment in the cytoplasm), and other nuclei were more spindle-shaped, consistent with fibroglial elements. The initial immunostains suggested an admixture of retinal pigment epithelium and retinal elements. Conclusion: To the authors' knowledge, this is the first study to use immunohistochemistry to elucidate the composition of these membranes. Future studies investigating the immunohistochemical profile of combined hamartomas are necessary.
AB - Purpose: To present the histologic and immunohistochemical findings of an epiretinal membrane overlying a combined hamartoma of the retina and retinal pigment epithelium. Methods: An interventional case report. Results: A 17-year-old healthy girl with a history of congenital cataract presented with a combined hamartoma of the retina and retinal pigment epithelium with prominent epiretinal membrane portion. Pars plana vitrectomy and membranectomy were performed, and the excised epiretinal membrane was submitted for routine histology and immunohistochemistry. Hematoxylin and eosin stain showed a monolayer of cells with an underlying basement membrane. Some of the nuclei were more epithelioid, consistent with retinal pigment epithelium (but without pigment in the cytoplasm), and other nuclei were more spindle-shaped, consistent with fibroglial elements. The initial immunostains suggested an admixture of retinal pigment epithelium and retinal elements. Conclusion: To the authors' knowledge, this is the first study to use immunohistochemistry to elucidate the composition of these membranes. Future studies investigating the immunohistochemical profile of combined hamartomas are necessary.
KW - Epiretinal membrane
KW - Hamartoma
KW - Immunohistochemistry
KW - Retinal pigment epithelium
UR - http://www.scopus.com/inward/record.url?scp=80052245400&partnerID=8YFLogxK
U2 - 10.1097/ICB.0b013e3181a59da4
DO - 10.1097/ICB.0b013e3181a59da4
M3 - Article
C2 - 25390398
AN - SCOPUS:80052245400
SN - 1935-1089
VL - 4
SP - 184
EP - 186
JO - Retinal Cases and Brief Reports
JF - Retinal Cases and Brief Reports
IS - 2
ER -