Histocompatibility Antigens and Primary Open-Angle Glaucoma: A Reassessment

Michael A. Kass, Paul Palmberg, Bernard Becker, J. Philip Miller

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Histocompatibility (HLA) antigen typing was performed on 306 patients who had been studied and classified carefully. Black individuals with primary open-angle glaucoma (POAG) had no significant differences in HLA antigen prevalences from black control subjects. In one white population with POAG, a significant decrease in HLA-A1, a significant increase in HLA-Aw31, and a significant increase in the antigen combination HLAB7 and HLA-Bw22 were noted. However, these differences were not confirmed in a second white population with POAG. We concluded that associations between the A and B loci of the HLA antigen system and POAG were not as impressive as has been previously reported.

Original languageEnglish
Pages (from-to)2207-2208
Number of pages2
JournalArchives of Ophthalmology
Issue number12
StatePublished - Dec 1978


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