Histochemical demonstration of a direct pathway from the fastigial nucleus to the septal region

Steven M. Paul, Robert G. Heath, Jeffrey P. Ellison

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

A cholinergic pathway from the fastigial nucleus to the septal region (including the septal nuclei proper, base of the head of the caudate nucleus, nucleus accumbens septi, and nucleus of the gyrus rectus) has been demonstrated in cats by use of the acetylcholinesterase (AChE) staining technique of Shute and Lewis. In cats autopsied 10-30 days after creation of fastigial nucleus lesions, the AChE staining diminished in the septal region on the side of the lesion. No changes in AChE staining were noted in control cats which had lesions elsewhere in the cerebellum. The pathway demonstrated by this technique corresponds closely to the pathway from the fastigial nucleus to the septal region which was previously demonstrated by electrophysiologic and histologic techniques and suggested by clinical data.

Original languageEnglish
Pages (from-to)798-805
Number of pages8
JournalExperimental Neurology
Volume40
Issue number3
DOIs
StatePublished - Sep 1973
Externally publishedYes

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