Hippocampal volume in type 1 diabetes

Michael Murray, Molly Stanley, Heather M. Lugar, Tamara Hershey

Research output: Contribution to journalArticlepeer-review


The hippocampus plays an important role in human memory and is known to be vulnerable to extreme hyperglycemia and hypoglycemia in animal models of type 1 diabetes. Within humans with type 1 diabetes, exposure to glycemic extremes has been associated with alterations in hippocampal structure and in memory function, but results are inconsistent. It has been hypothesized that the effects of hypoglycemia and hyperglycemia on the hippocampus may depend on when during neurodevelopment these extremes occur, possibly explaining some of these inconsistencies. However, data addressing this concept are limited. We review here the existing literature on this complex topic and suggest future avenues of required research.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalUS Endocrinology
Issue number2
StatePublished - 2013


  • Brain
  • Development
  • Diabetes
  • Hippocampus
  • Hyperglycemia
  • Hypoglycemia


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