Hippocampal volume in type 1 diabetes

Michael Murray, Molly Stanley, Heather M. Lugar, Tamara Hershey

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The hippocampus plays an important role in human memory and is known to be vulnerable to extreme hyperglycaemia and hypoglycaemia in animal models of type 1 diabetes. Within humans with type 1 diabetes, exposure to glycaemic extremes has been associated with alterations in hippocampal structure and in memory function, but results are inconsistent. It has been hypothesised that the effects of hypoglycaemia and hyperglycaemia on the hippocampus may depend on when during neurodevelopment these extremes occur, possibly explaining some of these inconsistencies. However, data addressing this concept are limited. We review here the existing literature on this complex topic and suggest future avenues of required research.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalEuropean Endocrinology
Issue number1
StatePublished - 2014


  • Brain
  • Development
  • Diabetes
  • Hippocampus
  • Hyperglycaemia
  • Hypoglycaemia


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