@article{b231d2ad626f4af0861da394ddd1e5ef,
title = "Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms",
abstract = "Hippo campal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat sensitivity may interact with arousal responses to alter hippocampal reactivity, and further how these interactions relate to the sequelae of trauma-related symptoms. In a sample of individuals recently exposed to trauma (N = 116, 76 female), we found that PTSD symptoms at 2 weeks were associated with decreased hippocampal responses to threat as assessed with fMRI. Further, the relationship between hippocampal threat sensitivity and PTSD symptomology only emerged in individuals who showed transient, high threat-related arousal, as assayed by an independently collected measure of fear potentiated startle. Collectively, our finding suggests that development of PTSD is associated with threat-related decreases in hippocampal function because of increases in fear-potentiated arousal.",
keywords = "arousal, fMRI, fear, hippocampus, trauma",
author = "B{\"u}{\c s}ra Tanriverdi and Gregory, {David F.} and Olino, {Thomas M.} and Ely, {Timothy D.} and Harnett, {Nathaniel G.} and {van Rooij}, {Sanne J.H.} and Lebois, {Lauren A.M.} and Seligowski, {Antonia V.} and Tanja Jovanovic and Ressler, {Kerry J.} and House, {Stacey L.} and Beaudoin, {Francesca L.} and Xinming An and Neylan, {Thomas C.} and Clifford, {Gari D.} and Linnstaedt, {Sarah D.} and Germine, {Laura T.} and Bollen, {Kenneth A.} and Rauch, {Scott L.} and Haran, {John P.} and Storrow, {Alan B.} and Christopher Lewandowski and Musey, {Paul I.} and Hendry, {Phyllis L.} and Sophia Sheikh and Jones, {Christopher W.} and Punches, {Brittany E.} and Kurz, {Michael C.} and McGrath, {Meghan E.} and Hudak, {Lauren A.} and Pascual, {Jose L.} and Seamon, {Mark J.} and Datner, {Elizabeth M.} and Claire Pearson and Domeier, {Robert M.} and Rathlev, {Niels K.} and O'Neil, {Brian J.} and Sanchez, {Leon D.} and Bruce, {Steven E.} and Miller, {Mark W.} and Pietrzak, {Robert H.} and Jutta Joormann and Barch, {Deanna M.} and Pizzagalli, {Diego A.} and Sheridan, {John F.} and Smoller, {Jordan W.} and Harte, {Steven E.} and Elliott, {James M.} and McLean, {Samuel A.} and Kessler, {Ronald C.} and Koenen, {Karestan C.} and Stevens, {Jennifer S.} and Murty, {Vishnu P.}",
note = "Funding Information: This work was supported by National Institute of Mental Health U01MH110925 to K.J.R., K00MH119603 to N.G.H., K01MH118467 to L.A.M.L., the U.S. Army Medical Research and Material Command, The One Mind Foundation, and The Mayday Fund. Verily Life Sciences and Mindstrong Health provided some of the hardware and software used to perform study assessments. Data and/or research tools used in the preparation of this manuscript were obtained from the National Institute of Mental Health Data Archive. The National Institute of Mental Health Data Archive is a collaborative informatics system created by the National Institutes of Health to provide a national resource to support and accelerate research in mental health. This manuscript reflects the views of the authors and may not reflect the opinions or views of the National Institutes of Health or of the submitters submitting original data to the National Institute of Mental Health Data Archive. Support for title page creation and format was provided by AuthorArranger, a tool developed at the National Cancer Institute. We thank the trauma survivors participating in the AURORA Study. Their time and effort during a challenging period of their lives make our efforts to improve recovery for future trauma survivors possible. Publisher Copyright: Copyright {\textcopyright} 2022 the authors.",
year = "2022",
month = aug,
day = "24",
doi = "10.1523/JNEUROSCI.0838-22.2022",
language = "English",
volume = "42",
pages = "6593--6604",
journal = "Journal of Neuroscience",
issn = "0270-6474",
number = "34",
}