Hippo gains weight: Added insights and complexity to pathway control

Leonie Enderle, Helen McNeill

Research output: Contribution to journalReview article

54 Scopus citations

Abstract

The Hippo pathway is a kinase cascade, formed by Hippo, Salvador, Warts, and Mats, that regulates the subcellular distribution and transcriptional activity of Yorkie. Yorkie is a transcriptional coactivator that promotes the expression of genes that inhibit apoptosis and drive cell proliferation. We review recent studies indicating that activity of the Hippo pathway is controlled by cell-cell junctions, cell adhesion molecules, scaffolding proteins, and cytoskeletal proteins, as well as by regulators of apical-basal polarity and extracellular tension.

Original languageEnglish
Article numberre7
JournalScience signaling
Volume6
Issue number296
DOIs
StatePublished - Oct 8 2013
Externally publishedYes

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