TY - JOUR
T1 - Highly sensitized patients listed for heart after liver transplantation with or without domino
AU - Lin, Shin
AU - Dimarakis, Ioannis
AU - Minami, Elina
AU - Bakthavatsalam, Ramasamy
AU - Bhattacharya, Renuka
AU - Stempien-Otero, April
AU - Lin, Yiing
AU - Karatasakis, Aris
AU - Khorsandi, Maziar
AU - Chou-Wu, Elaine
AU - Gimferrer, Idoia
AU - Golub, Mariya Y.
AU - Fishbein, Daniel
AU - Cheng, Richard K.
AU - Hirose, Ryutaro
AU - Sturdevant, Mark
AU - Pal, Jay D.
N1 - Publisher Copyright:
© 2024 International Society for the Heart and Lung Transplantation
PY - 2025/1
Y1 - 2025/1
N2 - For patients with end-stage heart disease and borderline hemodynamics, high human leukocyte antigen allosensitization presents a barrier to heart transplantation in a timely manner. Conventional desensitization protocols are inadequate in this context due to time constraints and for the most highly reactive immunologically. We previously reported performing heart after liver transplant with domino liver transplant on a single patient without liver disease. We describe this patient's course to date as well as 4 subsequent patients listed for this novel therapy. This experience demonstrates that the liver effectively confers immunoprotection to the heart for patients with high-titer, preformed antibodies. This strategy may provide some measure of equity for demographic groups previously disadvantaged for heart transplantation due to allosensitization.
AB - For patients with end-stage heart disease and borderline hemodynamics, high human leukocyte antigen allosensitization presents a barrier to heart transplantation in a timely manner. Conventional desensitization protocols are inadequate in this context due to time constraints and for the most highly reactive immunologically. We previously reported performing heart after liver transplant with domino liver transplant on a single patient without liver disease. We describe this patient's course to date as well as 4 subsequent patients listed for this novel therapy. This experience demonstrates that the liver effectively confers immunoprotection to the heart for patients with high-titer, preformed antibodies. This strategy may provide some measure of equity for demographic groups previously disadvantaged for heart transplantation due to allosensitization.
KW - allosensitization
KW - dual-organ transplant
KW - heart transplant
KW - liver transplant
KW - rejection
UR - http://www.scopus.com/inward/record.url?scp=85205214667&partnerID=8YFLogxK
U2 - 10.1016/j.healun.2024.08.024
DO - 10.1016/j.healun.2024.08.024
M3 - Article
C2 - 39222736
AN - SCOPUS:85205214667
SN - 1053-2498
VL - 44
SP - 125
EP - 128
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
IS - 1
ER -