High uptake of 68Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT

Harshad R. Kulkarni; Vikas Prasad; Daniel Kaemmerer; Merten Hommann; Richard P. Baum

doi:10.1007/978-3-642-27994-2_19

High uptake of ⁶⁸Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT

Harshad R. Kulkarni
, Vikas Prasad
, Daniel Kaemmerer
, Merten Hommann
, Richard P. Baum

Division of Nuclear Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

14 Scopus citations

Abstract

Aim: The aim of this study is to ascertain the high somatostatin receptor (SSTR) uptake in spleen and to compare the uptake in spleen and splenosis using SSTR PET/CT using ⁶⁸Ga-DOTATOC. Materials and Methods: SUV _max of spleen on ⁶⁸Ga-DOTATOC SSTR PET/CT (acquired for initial staging) in 10 patients with known neuroendocrine neoplasm of pancreatic tail was analyzed. All patients underwent left pancreatectomy and splenectomy. Diagnosis of splenosis was confirmed on CT, and SUV_max was noted on follow-up SSTR PET/CT. Results: SUV_maxwas 28.8 ± 12.5 in normal spleen and 10.5 ± 4.3 in splenosis. Conclusion: The high uptake of ⁶⁸Ga-DOTATOC (which has a high affinity to SSTR 2) in the spleen as compared to splenosis, which has a different histology, suggests white pulp as the probable site of high SSTR 2 expression.

Original language	English
Title of host publication	Theranostics, Gallium-68, and Other Radionuclides
Subtitle of host publication	A Pathway to Personalized Diagnosis and Treatment
Publisher	Springer Science and Business Media, LLC
Pages	373-378
Number of pages	6
ISBN (Print)	9783642279935
DOIs	https://doi.org/10.1007/978-3-642-27994-2_19
State	Published - 2013

Publication series

Name	Recent Results in Cancer Research
Volume	194
ISSN (Print)	0080-0015

Keywords

PET/CT
Somatostatin receptor
Splenosis

Access to Document

10.1007/978-3-642-27994-2_19

Cite this

Kulkarni, H. R., Prasad, V., Kaemmerer, D., Hommann, M., & Baum, R. P. (2013). High uptake of ⁶⁸Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT. In Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment (pp. 373-378). (Recent Results in Cancer Research; Vol. 194). Springer Science and Business Media, LLC. https://doi.org/10.1007/978-3-642-27994-2_19

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title = "High uptake of 68Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT",

abstract = "Aim: The aim of this study is to ascertain the high somatostatin receptor (SSTR) uptake in spleen and to compare the uptake in spleen and splenosis using SSTR PET/CT using 68Ga-DOTATOC. Materials and Methods: SUV max of spleen on 68Ga-DOTATOC SSTR PET/CT (acquired for initial staging) in 10 patients with known neuroendocrine neoplasm of pancreatic tail was analyzed. All patients underwent left pancreatectomy and splenectomy. Diagnosis of splenosis was confirmed on CT, and SUVmax was noted on follow-up SSTR PET/CT. Results: SUVmaxwas 28.8 ± 12.5 in normal spleen and 10.5 ± 4.3 in splenosis. Conclusion: The high uptake of 68Ga-DOTATOC (which has a high affinity to SSTR 2) in the spleen as compared to splenosis, which has a different histology, suggests white pulp as the probable site of high SSTR 2 expression.",

keywords = "PET/CT, Somatostatin receptor, Splenosis",

author = "Kulkarni, \{Harshad R.\} and Vikas Prasad and Daniel Kaemmerer and Merten Hommann and Baum, \{Richard P.\}",

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Kulkarni, HR, Prasad, V, Kaemmerer, D, Hommann, M & Baum, RP 2013, High uptake of ⁶⁸Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT. in Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment. Recent Results in Cancer Research, vol. 194, Springer Science and Business Media, LLC, pp. 373-378. https://doi.org/10.1007/978-3-642-27994-2_19

High uptake of ⁶⁸Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT. / Kulkarni, Harshad R.; Prasad, Vikas; Kaemmerer, Daniel et al.
Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment. Springer Science and Business Media, LLC, 2013. p. 373-378 (Recent Results in Cancer Research; Vol. 194).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - High uptake of 68Ga-DOTATOC in spleen as compared to splenosis

T2 - Measurement by PET/CT

AU - Kulkarni, Harshad R.

AU - Prasad, Vikas

AU - Kaemmerer, Daniel

AU - Hommann, Merten

AU - Baum, Richard P.

PY - 2013

Y1 - 2013

N2 - Aim: The aim of this study is to ascertain the high somatostatin receptor (SSTR) uptake in spleen and to compare the uptake in spleen and splenosis using SSTR PET/CT using 68Ga-DOTATOC. Materials and Methods: SUV max of spleen on 68Ga-DOTATOC SSTR PET/CT (acquired for initial staging) in 10 patients with known neuroendocrine neoplasm of pancreatic tail was analyzed. All patients underwent left pancreatectomy and splenectomy. Diagnosis of splenosis was confirmed on CT, and SUVmax was noted on follow-up SSTR PET/CT. Results: SUVmaxwas 28.8 ± 12.5 in normal spleen and 10.5 ± 4.3 in splenosis. Conclusion: The high uptake of 68Ga-DOTATOC (which has a high affinity to SSTR 2) in the spleen as compared to splenosis, which has a different histology, suggests white pulp as the probable site of high SSTR 2 expression.

AB - Aim: The aim of this study is to ascertain the high somatostatin receptor (SSTR) uptake in spleen and to compare the uptake in spleen and splenosis using SSTR PET/CT using 68Ga-DOTATOC. Materials and Methods: SUV max of spleen on 68Ga-DOTATOC SSTR PET/CT (acquired for initial staging) in 10 patients with known neuroendocrine neoplasm of pancreatic tail was analyzed. All patients underwent left pancreatectomy and splenectomy. Diagnosis of splenosis was confirmed on CT, and SUVmax was noted on follow-up SSTR PET/CT. Results: SUVmaxwas 28.8 ± 12.5 in normal spleen and 10.5 ± 4.3 in splenosis. Conclusion: The high uptake of 68Ga-DOTATOC (which has a high affinity to SSTR 2) in the spleen as compared to splenosis, which has a different histology, suggests white pulp as the probable site of high SSTR 2 expression.

KW - PET/CT

KW - Somatostatin receptor

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Kulkarni HR, Prasad V, Kaemmerer D, Hommann M, Baum RP. High uptake of ⁶⁸Ga-DOTATOC in spleen as compared to splenosis: Measurement by PET/CT. In Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment. Springer Science and Business Media, LLC. 2013. p. 373-378. (Recent Results in Cancer Research). doi: 10.1007/978-3-642-27994-2_19