Abstract
We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities. (Figure presented.).
Original language | English |
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Pages (from-to) | 792-798 |
Number of pages | 7 |
Journal | Journal of Biophotonics |
Volume | 10 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2017 |
Keywords
- blood flow redistribution
- cerebral autoregulation
- cortical hemodynamics
- MEMS scanning mirror
- microhemorrhage
- photoacoustic microscopy