High-speed photoacoustic microscopy of mouse cortical microhemodynamics

Li Lin, Junjie Yao, Ruiying Zhang, Chun Cheng Chen, Chih Hsien Huang, Yang Li, Lidai Wang, William Chapman, Jun Zou, Lihong V. Wang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities. (Figure presented.).

Original languageEnglish
Pages (from-to)792-798
Number of pages7
JournalJournal of Biophotonics
Volume10
Issue number6
DOIs
StatePublished - Jun 2017

Keywords

  • MEMS scanning mirror
  • blood flow redistribution
  • cerebral autoregulation
  • cortical hemodynamics
  • microhemorrhage
  • photoacoustic microscopy

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  • Cite this

    Lin, L., Yao, J., Zhang, R., Chen, C. C., Huang, C. H., Li, Y., Wang, L., Chapman, W., Zou, J., & Wang, L. V. (2017). High-speed photoacoustic microscopy of mouse cortical microhemodynamics. Journal of Biophotonics, 10(6), 792-798. https://doi.org/10.1002/jbio.201600236