High-speed photoacoustic microscopy of mouse cortical microhemodynamics

Li Lin, Junjie Yao, Ruiying Zhang, Chun Cheng Chen, Chih Hsien Huang, Yang Li, Lidai Wang, William Chapman, Jun Zou, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities. (Figure presented.).

Original languageEnglish
Pages (from-to)792-798
Number of pages7
JournalJournal of Biophotonics
Issue number6
StatePublished - Jun 2017


  • MEMS scanning mirror
  • blood flow redistribution
  • cerebral autoregulation
  • cortical hemodynamics
  • microhemorrhage
  • photoacoustic microscopy


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