High-sensitivity imaging and quantification of intratumoral distributions of gold nanoparticles using a benchtop x-ray fluorescence imaging system

Nivedh Manohar, Francisco Reynoso, Sandun Jayarathna, Hem Moktan, M. D.Foiez Ahmed, Parmeswaran Diagaradjane, Sunil Krishnan, Sang Hyun Cho

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A high-sensitivity benchtop x-ray fluorescence (XRF) imaging system, based on a high-power x-ray source and silicon drift detector, has been developed. This system allows gold L-shell XRF-based quantitative imaging of gold nanoparticles (GNPs) at concentrations as low as 0.007 mg∕cm3 (7 ppm) in biological tissues/water. Its capability for biomedical applications was demonstrated by imaging the GNP distribution within a small (∼12 × 11 × 2 mm3) ex vivo sample (extracted from a murine tumor after intravenous GNP administration). The results suggest direct translatability for routine preclinical ex vivo imaging tasks involving GNPs, as well as the possibility for in vivo imaging of small/superficial animal tumors.

Original languageEnglish
Pages (from-to)5314-5317
Number of pages4
JournalOptics Letters
Volume44
Issue number21
DOIs
StatePublished - Nov 1 2019

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