High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain

Mohammadreza Nasiriavanaki, Jun Xia, Hanlin Wan, Adam Quentin Bauer, Joseph P. Culver, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

259 Scopus citations


The increasing use of mouse models for human brain disease studies presents an emerging need for a new functional imaging modality. Using optical excitation and acoustic detection, we developed a functional connectivity photoacoustic tomography system, which allows noninvasive imaging of resting-state functional connectivity in the mouse brain, with a large field of view and a high spatial resolution. Bilateral correlations were observed in eight functional regions, including the olfactory bulb, limbic, parietal, somatosensory, retrosplenial, visual, motor, and temporal regions, as well as in several subregions. The borders and locations of these regions agreed well with the Paxinos mouse brain atlas. By subjecting the mouse to alternating hyperoxic and hypoxic conditions, strong and weak functional connectivities were observed, respectively. In addition to connectivity images, vascular images were simultaneously acquired. These studies show that functional connectivity photoacoustic tomography is a promising, noninvasive technique for functional imaging of the mouse brain.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number1
StatePublished - 2014


  • FcPAT
  • Hyperoxia
  • Hypoxia
  • Mouse brain functional imaging
  • RSFC


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