TY - GEN
T1 - High-resolution MR metabolic imaging
AU - Haldar, Justin P.
AU - Hernando, Diego
AU - Budde, Matthew D.
AU - Wang, Qing
AU - Song, Sheng Kwei
AU - Liang, Zhi Pei
PY - 2007
Y1 - 2007
N2 - Magnetic resonance spectroscopic imaging has been recognized for a long time as a powerful tool for bio- chemical imaging. However, its practical utility is still rather limited due to poor spatial resolution, low signal-to-noise ratio, and long data acquisition times. In this work, we propose a new technique that enables reconstruction of metabolite maps with high spatial resolution. This technique uses a statistical model to incorporate known anatomical boundaries for edge-preserving noise filtering. This statistical reconstruction scheme makes it possible to use very noisy data, thereby enabling the collection of high-resolution data in a reasonable amount of time. We illustrate the performance of this method with images of the N-acetyl-L-aspartate distribution from an in vivo mouse brain.
AB - Magnetic resonance spectroscopic imaging has been recognized for a long time as a powerful tool for bio- chemical imaging. However, its practical utility is still rather limited due to poor spatial resolution, low signal-to-noise ratio, and long data acquisition times. In this work, we propose a new technique that enables reconstruction of metabolite maps with high spatial resolution. This technique uses a statistical model to incorporate known anatomical boundaries for edge-preserving noise filtering. This statistical reconstruction scheme makes it possible to use very noisy data, thereby enabling the collection of high-resolution data in a reasonable amount of time. We illustrate the performance of this method with images of the N-acetyl-L-aspartate distribution from an in vivo mouse brain.
UR - http://www.scopus.com/inward/record.url?scp=57649205751&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2007.4353293
DO - 10.1109/IEMBS.2007.4353293
M3 - Conference contribution
C2 - 18002959
AN - SCOPUS:57649205751
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 4324
EP - 4326
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -