High-performance web services for querying gene and variant annotation

Jiwen Xin, Adam Mark, Cyrus Afrasiabi, Ginger Tsueng, Moritz Juchler, Nikhil Gopal, Gregory S. Stupp, Timothy E. Putman, Benjamin J. Ainscough, Obi L. Griffith, Ali Torkamani, Patricia L. Whetzel, Christopher J. Mungall, Sean D. Mooney, Andrew I. Su, Chunlei Wu

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://mygene.infoand http://myvariant.info. Both are offered free of charge to the research community.

Original languageEnglish
Article number91
JournalGenome biology
Volume17
Issue number1
DOIs
StatePublished - May 6 2016

Keywords

  • API
  • Annotation
  • Cloud
  • Database
  • Gene
  • Repository
  • Variant

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