TY - JOUR
T1 - High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition
AU - Hsieh, Ji Cheng
AU - Liu, Lei
AU - Zeilani, Mamane
AU - Ickes, Scott
AU - Trehan, Indi
AU - Maleta, Ken
AU - Craig, Christina
AU - Thakwalakwa, Chrissie
AU - Singh, Lauren
AU - Thomas Brenna, J.
AU - Manary, Mark J.
N1 - Publisher Copyright:
© 2015 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.
PY - 2015/7/23
Y1 - 2015/7/23
N2 - Objectives: Ready-to-use therapeutic food (RUTF) is the preferred treatment for uncomplicated severe acute malnutrition. It contains large amounts of linoleic acid and little α-linolenic acid, which may reduce the availability of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to the recovering child. A novel high-oleic RUTF (HO-RUTF) was developed with less linoleic acid to determine its effect on DHA and EPA status. Methods: We conducted a prospective, randomized, double-blind clinical effectiveness trial treating rural Malawian children with severe acute malnutrition. Children were treated with either HO-RUTF or standard RUTF. Plasma phospholipid fatty acid status was measured on enrollment and after 4 weeks and compared between the 2 intervention groups. Results: Among the 141 children enrolled, 48 of 71 receiving HO-RUTF and 50 of 70 receiving RUTF recovered. Plasma phospholipid samples were analyzed from 43 children consuming HO-RUTF and 35 children consuming RUTF. The change in DHA content during the first 4 weeks was +4% and-25% in the HO-RUTF and RUTF groups, respectively (P = 0.04). For EPA, the change in content was 63% and-24% in the HO-RUTF and RUTF groups, respectively (P < 0.001). For arachidonic acid, the change in content was-3% and 13% in the HO-RUTF and RUTF groups, respectively (P < 0.009). Conclusions: The changes in DHA and EPA seen in the children treated with HO-RUTF warrant further investigation because they suggest that HO-RUTF support improved polyunsaturated fatty acid status, necessary for neural development and recovery.
AB - Objectives: Ready-to-use therapeutic food (RUTF) is the preferred treatment for uncomplicated severe acute malnutrition. It contains large amounts of linoleic acid and little α-linolenic acid, which may reduce the availability of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to the recovering child. A novel high-oleic RUTF (HO-RUTF) was developed with less linoleic acid to determine its effect on DHA and EPA status. Methods: We conducted a prospective, randomized, double-blind clinical effectiveness trial treating rural Malawian children with severe acute malnutrition. Children were treated with either HO-RUTF or standard RUTF. Plasma phospholipid fatty acid status was measured on enrollment and after 4 weeks and compared between the 2 intervention groups. Results: Among the 141 children enrolled, 48 of 71 receiving HO-RUTF and 50 of 70 receiving RUTF recovered. Plasma phospholipid samples were analyzed from 43 children consuming HO-RUTF and 35 children consuming RUTF. The change in DHA content during the first 4 weeks was +4% and-25% in the HO-RUTF and RUTF groups, respectively (P = 0.04). For EPA, the change in content was 63% and-24% in the HO-RUTF and RUTF groups, respectively (P < 0.001). For arachidonic acid, the change in content was-3% and 13% in the HO-RUTF and RUTF groups, respectively (P < 0.009). Conclusions: The changes in DHA and EPA seen in the children treated with HO-RUTF warrant further investigation because they suggest that HO-RUTF support improved polyunsaturated fatty acid status, necessary for neural development and recovery.
KW - docosahexaenoic acid
KW - eicosapentaenoic acid
KW - linolenic acid
KW - ready-to-use therapeutic food
KW - severe acute malnutrition
UR - http://www.scopus.com/inward/record.url?scp=84937727832&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000000741
DO - 10.1097/MPG.0000000000000741
M3 - Article
C2 - 25633498
AN - SCOPUS:84937727832
SN - 0277-2116
VL - 61
SP - 138
EP - 143
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 1
ER -