TY - JOUR
T1 - High-grade cervical disease in adolescents with HIV
AU - Massad, L. Stewart
AU - Evans, Charlesnika T.
AU - D'Souza, Gypsyamber
AU - Darragh, Teresa
AU - Minkoff, Howard
AU - Henry, Donna
AU - Goparaju, Lakshmi
AU - Muderspach, Laila I.
AU - Watts, D. Heather
PY - 2008/7
Y1 - 2008/7
N2 - Objective. To estimate the risk of high-grade squamous intraepithelial lesions (HSIL) in adolescents with HIV. Materials and Methods. Review of cervical cytology and biopsy Results from women aged 20 years and younger obtained within 3 years of enrollment in a prospective multicenter study. Results. At enrollment, none of 132 adolescent participants (45 HIV seropositive and 87 seronegative) had HSIL or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2,3). Eight (7%) of 123 women with follow-up developed high-grade disease after a median of 2.6 years of observation. The incidence of HSIL/CIN 2,3 was 2.7/100 person-years (4.8/100 person-years in HIV seropositive and 1.6/100 person-years in HIV seronegative women; relative risk = 3.1; 95% CI = 0.76-12.74; p =.13). No cancers were found in adolescents during the study. Conclusions. The low incidence of HSIL or CIN 2,3 in adolescents suggests that optimal management is careful observation rather than preventive treatment of low-grade abnormalities.
AB - Objective. To estimate the risk of high-grade squamous intraepithelial lesions (HSIL) in adolescents with HIV. Materials and Methods. Review of cervical cytology and biopsy Results from women aged 20 years and younger obtained within 3 years of enrollment in a prospective multicenter study. Results. At enrollment, none of 132 adolescent participants (45 HIV seropositive and 87 seronegative) had HSIL or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2,3). Eight (7%) of 123 women with follow-up developed high-grade disease after a median of 2.6 years of observation. The incidence of HSIL/CIN 2,3 was 2.7/100 person-years (4.8/100 person-years in HIV seropositive and 1.6/100 person-years in HIV seronegative women; relative risk = 3.1; 95% CI = 0.76-12.74; p =.13). No cancers were found in adolescents during the study. Conclusions. The low incidence of HSIL or CIN 2,3 in adolescents suggests that optimal management is careful observation rather than preventive treatment of low-grade abnormalities.
KW - Adolescents
KW - Cervical cancer prevention
KW - HIV in women
KW - HPV
KW - Pap test
UR - http://www.scopus.com/inward/record.url?scp=50549092552&partnerID=8YFLogxK
U2 - 10.1097/LGT.0b013e318160b9a5
DO - 10.1097/LGT.0b013e318160b9a5
M3 - Article
C2 - 18596461
AN - SCOPUS:50549092552
SN - 1089-2591
VL - 12
SP - 199
EP - 203
JO - Journal of lower genital tract disease
JF - Journal of lower genital tract disease
IS - 3
ER -