High-frequency ultrasonic detection of thrombi with a targeted contrast system

Gregory M. Lanza, Kirk D. Wallace, Stefan E. Fischer, Donald H. Christy, Michael J. Scott, Rebecca L. Trousil, William P. Cacheris, James G. Miller, Patrick J. Gaffney, Samuel A. Wickline

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Site-targeted acoustic contrast agents used in conjunction with high- frequency intravascular ultrasound have the potential to localize and characterize intravascular pathology. The present study quantifies the utility of a novel, site-targeted ultrasonic contrast agent with high- frequency ultrasound (30 to 50 MHz) and demonstrates the feasibility of the new agent for augmenting detection of targeted pathology with intravascular ultrasonic catheters. High-frequency acoustic microscopy was used to image avidinconjugated nitrocellulose membranes after exposure to a control or biotinylated contrast agent. Increases (p < 0.05) in backscattered power of approximately 6 dB(4-fold) were found for the biotinylated, but not the control contrast agent. Intravascular ultrasonic images (30 MHz nominal center frequency) of plasma clots after exposure to the targeted contrast agent were brighter (p < 0.05) than controls. These results demonstrate high- frequency acoustic enhancement with a novel targeted contrast agent and may extend the potential diagnostic spectrum of intravascular ultrasound.

Original languageEnglish
Pages (from-to)863-870
Number of pages8
JournalUltrasound in Medicine and Biology
Volume23
Issue number6
DOIs
StatePublished - 1997

Keywords

  • Acoustic
  • Avidin
  • Biotin
  • Contrast
  • Echocardiography
  • Fibrin
  • Intravascular ultrasound
  • Perfluorocarbon
  • Targeted
  • Thrombus

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