The pseudoautosomal region (PAR) is a segment of shared homology between the X and Y chromosomes. Here we report physical linkage of three mouse PAR probes: DXYHgu1, DXYMov15 and (TTAGGG)(n). Steroid sulphatase (Sts) maps distal to these three probes, indicating that there is an internal array of the telomere sequence (TTAGGG)(n) in the PAR. Pseudoautosomal Pac1 restriction fragments, up to 2 Mb in size, are unstable in C57BL/6 x C57BL/6 crosses. New alleles, often several hundred kilobases different in size, occur at a sex-averaged rate of ~30% per allele. Such frequent large-scale germline genome rearrangements are without precedent in mammals.
|Number of pages||5|
|State||Published - May 1 1996|