High ER stress in β-cells stimulates intracellular degradation of misfolded insulin

Jenny R. Allen, Linh X. Nguyen, Karen E.G. Sargent, Kathryn L. Lipson, Anthony Hackett, Fumihiko Urano

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Endoplasmic reticulum (ER) stress, which is caused by the accumulation of misfolded proteins in the ER, elicits an adaptive response, the unfolded protein response (UPR). One component of the UPR, the endoplasmic reticulum-associated protein degradation (ERAD) system, has an important function in the survival of ER stressed cells. Here, we show that HRD1, a component of the ERAD system, is upregulated in pancreatic islets of the Akita diabetes mouse model and enhances intracellular degradation of misfolded insulin. High ER stress in β-cells stimulated mutant insulin degradation through HRD1 to protect β-cells from ER stress and ensuing death. If HRD1 serves the same function in humans, it may serve as a target for therapeutic intervention in diabetes.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume324
Issue number1
DOIs
StatePublished - Nov 5 2004

Keywords

  • Diabetes
  • Endoplasmic reticulum stress
  • Endoplasmic-reticulum associated protein degradation
  • Unfolded protein response

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