High-efficiency dialysis for carbamazepine overdose

Douglas J.E. Schuerer, Patrick D. Brophy, Norma J. Maxvold, Timothy Kudelka, Timothy E. Bunchman

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Background: Carbamazepine intoxication is associated with seizures, coma, arrhythmias, and death. In acute intoxications, charcoal hemoperfusion enhances removal of the drug but is associated with thrombocytopenia, coagulopathy, hypothermia, and hypocalcemia. Alternatively, high-efficiency hemodialysis can be used without the side effects of charcoal hemoperfusion. Case Report: We report an 18-month-old comatose, convulsing child with plasma carbamazepine 27 μg/mL treated with high efficiency hemodialysis. Therapeutic carbamazepine levels were obtained after 4.5 hours of high- efficiency hemodialysis. The patient developed no untoward side effects, improved clinically, and was subsequently discharged home without sequelae. We conclude that high-efficiency hemodialysis is a safe, effective alternative to charcoal hemoperfusion in the pediatric population.

Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalJournal of Toxicology - Clinical Toxicology
Issue number3
StatePublished - Jul 3 2000


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