TY - JOUR
T1 - High-efficiency dialysis for carbamazepine overdose
AU - Schuerer, Douglas J.E.
AU - Brophy, Patrick D.
AU - Maxvold, Norma J.
AU - Kudelka, Timothy
AU - Bunchman, Timothy E.
PY - 2000
Y1 - 2000
N2 - Background: Carbamazepine intoxication is associated with seizures, coma, arrhythmias, and death. In acute intoxications, charcoal hemoperfusion enhances removal of the drug but is associated with thrombocytopenia, coagulopathy, hypothermia, and hypocalcemia. Alternatively, high-efficiency hemodialysis can be used without the side effects of charcoal hemoperfusion. Case Report: We report an 18-month-old comatose, convulsing child with plasma carbamazepine 27 μg/mL treated with high efficiency hemodialysis. Therapeutic carbamazepine levels were obtained after 4.5 hours of high- efficiency hemodialysis. The patient developed no untoward side effects, improved clinically, and was subsequently discharged home without sequelae. We conclude that high-efficiency hemodialysis is a safe, effective alternative to charcoal hemoperfusion in the pediatric population.
AB - Background: Carbamazepine intoxication is associated with seizures, coma, arrhythmias, and death. In acute intoxications, charcoal hemoperfusion enhances removal of the drug but is associated with thrombocytopenia, coagulopathy, hypothermia, and hypocalcemia. Alternatively, high-efficiency hemodialysis can be used without the side effects of charcoal hemoperfusion. Case Report: We report an 18-month-old comatose, convulsing child with plasma carbamazepine 27 μg/mL treated with high efficiency hemodialysis. Therapeutic carbamazepine levels were obtained after 4.5 hours of high- efficiency hemodialysis. The patient developed no untoward side effects, improved clinically, and was subsequently discharged home without sequelae. We conclude that high-efficiency hemodialysis is a safe, effective alternative to charcoal hemoperfusion in the pediatric population.
UR - http://www.scopus.com/inward/record.url?scp=0034046350&partnerID=8YFLogxK
U2 - 10.1081/CLT-100100938
DO - 10.1081/CLT-100100938
M3 - Article
C2 - 10866333
AN - SCOPUS:0034046350
SN - 0731-3810
VL - 38
SP - 321
EP - 323
JO - Journal of Toxicology - Clinical Toxicology
JF - Journal of Toxicology - Clinical Toxicology
IS - 3
ER -