High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain

Tanja Dragojević, Hari M. Varma, Joseph L. Hollmann, Claudia P. Valdes, Joseph P. Culver, Carles Justicia, Turgut Durduran

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

High-density speckle contrast optical tomography (SCOT) utilizing tens of thousands of source-detector pairs, was developed for in vivo imaging of blood flow in small animals. The reduction in cerebral blood flow (CBF) due to local ischemic stroke in a mouse brain was transcanially imaged and reconstructed in three dimensions. The reconstructed volume was then compared with corresponding magnetic resonance images demonstrating that the volume of reduced CBF agrees with the infarct zone at twenty-four hours.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
JournalNeuroImage
Volume153
DOIs
StatePublished - Jun 2017

Keywords

  • (110.3010) Image reconstruction techniques
  • (110.6150) Speckle imaging
  • (170.3880) Medical and biological imaging
  • OCIS codes

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