High-density lipoprotein levels and 10-year cardiovascular risk in HIV-1-infected patients

Aoife G. Cotter, Claudette S. Satchell, Jane A. O'Halloran, Eoin R. Feeney, Caroline A. Sabin, Patrick W.G. Mallon

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We aimed to determine the contribution of high-density lipoprotein cholesterol (HDL-c) to cardiovascular disease (CVD) risk in a cohort of HIV-infected patients. The contribution of CVD risk factors to the predicted CVD risk was assessed. We estimated the degree of reclassification of CVD risk if HDL-c concentration was increased in all patients by 20 and 40%, respectively. After age, HDL-c contributed most to the overall cardiovascular risk. Increasing HDL-c by 20% and 40% reclassified six and 12 patients to lower CVD risk groups, respectively. In this cohort, HDL-c contributed more to cardiovascular risk than smoking, total cholesterol, systolic blood pressure (SBP) and sex.

Original languageEnglish
Pages (from-to)867-869
Number of pages3
JournalAIDS
Volume25
Issue number6
DOIs
StatePublished - Mar 27 2011

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