TY - JOUR
T1 - High-density lipoprotein levels and 10-year cardiovascular risk in HIV-1-infected patients
AU - Cotter, Aoife G.
AU - Satchell, Claudette S.
AU - O'Halloran, Jane A.
AU - Feeney, Eoin R.
AU - Sabin, Caroline A.
AU - Mallon, Patrick W.G.
PY - 2011/3/27
Y1 - 2011/3/27
N2 - We aimed to determine the contribution of high-density lipoprotein cholesterol (HDL-c) to cardiovascular disease (CVD) risk in a cohort of HIV-infected patients. The contribution of CVD risk factors to the predicted CVD risk was assessed. We estimated the degree of reclassification of CVD risk if HDL-c concentration was increased in all patients by 20 and 40%, respectively. After age, HDL-c contributed most to the overall cardiovascular risk. Increasing HDL-c by 20% and 40% reclassified six and 12 patients to lower CVD risk groups, respectively. In this cohort, HDL-c contributed more to cardiovascular risk than smoking, total cholesterol, systolic blood pressure (SBP) and sex.
AB - We aimed to determine the contribution of high-density lipoprotein cholesterol (HDL-c) to cardiovascular disease (CVD) risk in a cohort of HIV-infected patients. The contribution of CVD risk factors to the predicted CVD risk was assessed. We estimated the degree of reclassification of CVD risk if HDL-c concentration was increased in all patients by 20 and 40%, respectively. After age, HDL-c contributed most to the overall cardiovascular risk. Increasing HDL-c by 20% and 40% reclassified six and 12 patients to lower CVD risk groups, respectively. In this cohort, HDL-c contributed more to cardiovascular risk than smoking, total cholesterol, systolic blood pressure (SBP) and sex.
UR - http://www.scopus.com/inward/record.url?scp=79953757238&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e32834507f0
DO - 10.1097/QAD.0b013e32834507f0
M3 - Article
C2 - 21330909
AN - SCOPUS:79953757238
SN - 0269-9370
VL - 25
SP - 867
EP - 869
JO - AIDS
JF - AIDS
IS - 6
ER -