TY - JOUR
T1 - Hierarchical and nonhierarchical features of the mouse visual cortical network
AU - D’Souza, Rinaldo D.
AU - Wang, Quanxin
AU - Ji, Weiqing
AU - Meier, Andrew M.
AU - Kennedy, Henry
AU - Knoblauch, Kenneth
AU - Burkhalter, Andreas
N1 - Funding Information:
This work was supported by the National Eye Institute (R01 EY016184, R01 EY020523, R01 EY022090, and R01 EY027383 to A.B.), and LABEX CORTEX (ANR-11-LABX-0042 to H.K.) of Université de Lyon (ANR-11-IDEX-0007) operated by the French National Research Agency (ANR), (ANR-15-CE32-0016 CORNET to H.K.), (ANR-17-NEUC-0004 to H.K.), (A2P2MC to H.K.), (ANR-17-HBPR-0003, CORTICITY to H.K.), and (ANR-19-CE37-0000, DUAL_STREAMS to K.K.).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Neocortical computations underlying vision are performed by a distributed network of functionally specialized areas. Mouse visual cortex, a dense interareal network that exhibits hierarchical properties, comprises subnetworks interconnecting distinct processing streams. To determine the layout of the mouse visual hierarchy, we have evaluated the laminar patterns formed by interareal axonal projections originating in each of ten areas. Reciprocally connected pairs of areas exhibit feedforward/feedback relationships consistent with a hierarchical organization. Beta regression analyses, which estimate a continuous hierarchical distance measure, indicate that the network comprises multiple nonhierarchical circuits embedded in a hierarchical organization of overlapping levels. Single-unit recordings in anaesthetized mice show that receptive field sizes are generally consistent with the hierarchy, with the ventral stream exhibiting a stricter hierarchy than the dorsal stream. Together, the results provide an anatomical metric for hierarchical distance, and reveal both hierarchical and nonhierarchical motifs in mouse visual cortex.
AB - Neocortical computations underlying vision are performed by a distributed network of functionally specialized areas. Mouse visual cortex, a dense interareal network that exhibits hierarchical properties, comprises subnetworks interconnecting distinct processing streams. To determine the layout of the mouse visual hierarchy, we have evaluated the laminar patterns formed by interareal axonal projections originating in each of ten areas. Reciprocally connected pairs of areas exhibit feedforward/feedback relationships consistent with a hierarchical organization. Beta regression analyses, which estimate a continuous hierarchical distance measure, indicate that the network comprises multiple nonhierarchical circuits embedded in a hierarchical organization of overlapping levels. Single-unit recordings in anaesthetized mice show that receptive field sizes are generally consistent with the hierarchy, with the ventral stream exhibiting a stricter hierarchy than the dorsal stream. Together, the results provide an anatomical metric for hierarchical distance, and reveal both hierarchical and nonhierarchical motifs in mouse visual cortex.
UR - http://www.scopus.com/inward/record.url?scp=85123803511&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-28035-y
DO - 10.1038/s41467-022-28035-y
M3 - Article
C2 - 35082302
AN - SCOPUS:85123803511
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 503
ER -