TY - JOUR
T1 - Heterogeneous liver on research ultrasound identifies children with cystic fibrosis at high risk of advanced liver disease
AU - Siegel, Marilyn J.
AU - Leung, Daniel H.
AU - Molleston, Jean P.
AU - Ye, Wen
AU - Paranjape, Shruti M.
AU - Freeman, A. Jay
AU - Palermo, Joseph J.
AU - Stoll, Janis
AU - Masand, Prakash
AU - Karmazyn, Boaz
AU - Harned, Roger
AU - Ling, Simon C.
AU - Navarro, Oscar M.
AU - Karnsakul, Wikrom
AU - Alazraki, Adina
AU - Schwarzenberg, Sarah Jane
AU - Towbin, Alex J.
AU - Alonso, Estella M.
AU - Nicholas, Jennifer L.
AU - Green, Nicole
AU - Otto, Randolph K.
AU - Magee, John C.
AU - Narkewicz, Michael R.
N1 - Publisher Copyright:
© 2023 European Cystic Fibrosis Society
PY - 2023/7
Y1 - 2023/7
N2 - Background: This study examines whether heterogeneous (HTG) pattern on liver ultrasound (US) identifies children at risk for advanced cystic fibrosis liver disease (aCFLD). Methods: Prospective 6-year multicenter case-controlled cohort study. Children with pancreatic insufficient cystic fibrosis (CF) aged 3–12 years without known cirrhosis underwent screening US. Participants with HTG were matched (by age, Pseudomonas infection status and center) 1:2 with participants with normal (NL) US pattern. Clinical status and laboratory data were obtained annually and US bi-annually for 6 years. Primary endpoint was development of nodular (NOD) US pattern consistent with aCFLD. Results: 722 participants underwent screening US, with 65 HTG and 592 NL. Final cohort included 55 HTG and 116 NL with ≥ 1 follow-up US. ALT, AST, GGTP, FIB-4, GPR and APRI were higher, and platelets were lower in HTG compared to NL. HTG had a 9.5-fold increased incidence (95% confidence interval [CI]:3.4, 26.7, p<0.0001, 32.7% vs 3.4%) of NOD versus NL. HTG had a sensitivity of 82% and specificity of 75% for subsequent NOD. Negative predictive value of a NL US for subsequent NOD was 96%. Multivariate logistic prediction model that included baseline US, age, and log(GPR) improved the C-index to 0.90 compared to only baseline US (C-index 0.78). Based on survival analysis, 50% of HTG develop NOD after 8 years. Conclusions: Research US finding of HTG identifies children with CF with a 30–50% risk for aCFLD. A score based on US pattern, age and GPR may refine the identification of individuals at high risk for aCFLD.
AB - Background: This study examines whether heterogeneous (HTG) pattern on liver ultrasound (US) identifies children at risk for advanced cystic fibrosis liver disease (aCFLD). Methods: Prospective 6-year multicenter case-controlled cohort study. Children with pancreatic insufficient cystic fibrosis (CF) aged 3–12 years without known cirrhosis underwent screening US. Participants with HTG were matched (by age, Pseudomonas infection status and center) 1:2 with participants with normal (NL) US pattern. Clinical status and laboratory data were obtained annually and US bi-annually for 6 years. Primary endpoint was development of nodular (NOD) US pattern consistent with aCFLD. Results: 722 participants underwent screening US, with 65 HTG and 592 NL. Final cohort included 55 HTG and 116 NL with ≥ 1 follow-up US. ALT, AST, GGTP, FIB-4, GPR and APRI were higher, and platelets were lower in HTG compared to NL. HTG had a 9.5-fold increased incidence (95% confidence interval [CI]:3.4, 26.7, p<0.0001, 32.7% vs 3.4%) of NOD versus NL. HTG had a sensitivity of 82% and specificity of 75% for subsequent NOD. Negative predictive value of a NL US for subsequent NOD was 96%. Multivariate logistic prediction model that included baseline US, age, and log(GPR) improved the C-index to 0.90 compared to only baseline US (C-index 0.78). Based on survival analysis, 50% of HTG develop NOD after 8 years. Conclusions: Research US finding of HTG identifies children with CF with a 30–50% risk for aCFLD. A score based on US pattern, age and GPR may refine the identification of individuals at high risk for aCFLD.
KW - Cirrhosis
KW - Cystic fibrosis liver disease
UR - http://www.scopus.com/inward/record.url?scp=85152400204&partnerID=8YFLogxK
U2 - 10.1016/j.jcf.2023.03.019
DO - 10.1016/j.jcf.2023.03.019
M3 - Article
C2 - 37032248
AN - SCOPUS:85152400204
SN - 1569-1993
VL - 22
SP - 745
EP - 755
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 4
ER -