Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

Simone Brioschi, Wei Le Wang, Vincent Peng, Meng Wang, Irina Shchukina, Zev J. Greenberg, Jennifer K. Bando, Natalia Jaeger, Rafael S. Czepielewski, Amanda Swain, Denis A. Mogilenko, Wandy L. Beatty, Peter Bayguinov, James A.J. Fitzpatrick, Laura G. Schuettpelz, Catrina C. Fronick, Igor Smirnov, Jonathan Kipnis, Virginia S. Shapiro, Gregory F. WuSusan Gilfillan, Marina Cella, Maxim N. Artyomov, Steven H. Kleinstein, Marco Colonna

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging, bone marrow chimeras, and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvarial–meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells, which may help maintain immune privilege within the CNS.

Original languageEnglish
Article numbereabf9277
JournalScience
Volume373
Issue number6553
DOIs
StatePublished - Jul 23 2021

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