Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity

M. J. Holtzman; A. Pentland; N. L. Baenziger; J. R. Hansbrough

doi:10.1016/0005-2760(89)90257-9

Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity

M. J. Holtzman, A. Pentland, N. L. Baenziger, J. R. Hansbrough

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Comparison of relative arachidonate 15-lipoxygenase activities in different types of human cell reveals striking differences in levels of product generation. Among available human cell types, the tracheal epithelial cell and the eosinophil have markedly higher levels of activity than other cell types with reported activity. Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types.

Original language	English
Pages (from-to)	204-208
Number of pages	5
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	1003
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(89)90257-9
State	Published - Jun 8 1989

Keywords

Cyclooxygenase
Leukotriene
Lipoxygenase
Prostaglandin

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10.1016/0005-2760(89)90257-9

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title = "Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity",

abstract = "Comparison of relative arachidonate 15-lipoxygenase activities in different types of human cell reveals striking differences in levels of product generation. Among available human cell types, the tracheal epithelial cell and the eosinophil have markedly higher levels of activity than other cell types with reported activity. Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types.",

keywords = "Cyclooxygenase, Leukotriene, Lipoxygenase, Prostaglandin",

author = "Holtzman, {M. J.} and A. Pentland and Baenziger, {N. L.} and Hansbrough, {J. R.}",

note = "Funding Information: This researchw as supportedb y Grants HL40078, HL33699,H L36409,A M38111,a nd AR01496f rom the National Instituteso f Health. M.J.H. is the Schering Career Investigatoro f the AmericanL ung Association and J.R.H. is a Parker B. Francis Fellow.",

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doi = "10.1016/0005-2760(89)90257-9",

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T1 - Heterogeneity of cellular expression of arachidonate 15-lipoxygenase

T2 - implications for biological activity

AU - Holtzman, M. J.

AU - Pentland, A.

AU - Baenziger, N. L.

AU - Hansbrough, J. R.

N1 - Funding Information: This researchw as supportedb y Grants HL40078, HL33699,H L36409,A M38111,a nd AR01496f rom the National Instituteso f Health. M.J.H. is the Schering Career Investigatoro f the AmericanL ung Association and J.R.H. is a Parker B. Francis Fellow.

PY - 1989/6/8

Y1 - 1989/6/8

N2 - Comparison of relative arachidonate 15-lipoxygenase activities in different types of human cell reveals striking differences in levels of product generation. Among available human cell types, the tracheal epithelial cell and the eosinophil have markedly higher levels of activity than other cell types with reported activity. Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types.

AB - Comparison of relative arachidonate 15-lipoxygenase activities in different types of human cell reveals striking differences in levels of product generation. Among available human cell types, the tracheal epithelial cell and the eosinophil have markedly higher levels of activity than other cell types with reported activity. Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types.

KW - Cyclooxygenase

KW - Leukotriene

KW - Lipoxygenase

KW - Prostaglandin

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SN - 0005-2760

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JO - Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

JF - Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

IS - 2

ER -

Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity

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Keywords

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