Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity

M. J. Holtzman, A. Pentland, N. L. Baenziger, J. R. Hansbrough

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Comparison of relative arachidonate 15-lipoxygenase activities in different types of human cell reveals striking differences in levels of product generation. Among available human cell types, the tracheal epithelial cell and the eosinophil have markedly higher levels of activity than other cell types with reported activity. Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1003
Issue number2
DOIs
StatePublished - Jun 8 1989

Keywords

  • Cyclooxygenase
  • Leukotriene
  • Lipoxygenase
  • Prostaglandin

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