@article{20fb8fe4884b4378b5fd55f6146f40c6,
title = "Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses",
abstract = "In the upper respiratory tract, different cell types respond in different ways early after viral infection. Dumm et al. show that influenza B virus targets olfactory sensory neurons, but these neurons induce interferon-stimulated genes to rapidly clear the virus non-lytically and protect the CNS from disseminated infection.",
keywords = "central nervous system, epithelial cells, inflammation, interferon stimulated genes, olfactory sensory neurons, respiratory viruses, viral clearance",
author = "Dumm, {Rebekah E.} and Wellford, {Sebastian A.} and Moseman, {E. Ashley} and Heaton, {Nicholas S.}",
note = "Funding Information: We would like to acknowledge assistance from Mike Cook and the Duke Cancer Institute Flow Cytometry Core, as well as the Duke Light Microscopy Core Facility. We would like to thank David Sachs for development of the bioinformatic applications to map sequencing reads to the mouse transcriptome and the influenza genome. We would also like to thank Ben Chambers, Brook Heaton, and Heather Froggatt for critical reading of this manuscript and Hiroaki Matsunami (as well as members of his laboratory) for helpful discussions. N.S.H. is partially supported by grants from the National Heart, Lung, and Blood Institute ( R01-HL142985 ) and the National Institute of Allergy and Infectious Diseases ( R01-AI137031 ). E.A.M. is partially supported by the Duke School of Medicine Whitehead Family Scholarship . Funding Information: We would like to acknowledge assistance from Mike Cook and the Duke Cancer Institute Flow Cytometry Core, as well as the Duke Light Microscopy Core Facility. We would like to thank David Sachs for development of the bioinformatic applications to map sequencing reads to the mouse transcriptome and the influenza genome. We would also like to thank Ben Chambers, Brook Heaton, and Heather Froggatt for critical reading of this manuscript and Hiroaki Matsunami (as well as members of his laboratory) for helpful discussions. N.S.H. is partially supported by grants from the National Heart, Lung, and Blood Institute (R01-HL142985) and the National Institute of Allergy and Infectious Diseases (R01-AI137031). E.A.M. is partially supported by the Duke School of Medicine Whitehead Family Scholarship. R.E.D. E.A.M. and N.S.H. designed the study. R.E.D. E.A.M. and S.A.W. performed experiments. R.E.D. S.A.W. E.A.M. and N.S.H. performed data analysis and interpretation. R.E.D. E.A.M. and N.S.H. wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = sep,
day = "1",
doi = "10.1016/j.celrep.2020.108103",
language = "English",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
number = "9",
}