TY - JOUR
T1 - Heterogeneity between populations for multifactorial inheritance of plasma lipids
AU - Rao, D. C.
AU - Morton, N. E.
AU - Glueck, C. J.
AU - Laskarzewski, P. M.
AU - Russell, J. M.
PY - 1983
Y1 - 1983
N2 - A general linear model was described for multifactorial inheritance of the two plasma lipids, total cholesterol (CH), and triglyceride (TG). Analyses of two separate studies, the Honolulu Heart Study (HHS) and the Cincinnati Lipid Research Clinic (LRC), indicated some heterogeneity. Whereas the sibling environmental effect (b) was the only source of heterogeneity between the two studies for TG, the correlation between marital environments (u) may also be considered as a source of heterogeneity for CH. Under parsimonious hypothesis, intergenerational differences in heritabilities were not found to be significant for either trait (y1 = y2 = z1 = z2 = 1). Maternal effects were significant for CH but not for TG. Correlations between marital environments (1 and u2) were not significant for TG, and may be considered nonsignificant for CH also under parsimonious hypotheses. In any case, the genetic (h2) and cultural (c2) heritabilities cannot be considered to be heterogeneous between the two studies. Based on pooled data, parsimonious hypothesis yields: h2 = .594 ± .041 and c2 = .035 ± .008 for CH, and h2 = .259 ± .034 and c2 = .108 ± .014 for TG.
AB - A general linear model was described for multifactorial inheritance of the two plasma lipids, total cholesterol (CH), and triglyceride (TG). Analyses of two separate studies, the Honolulu Heart Study (HHS) and the Cincinnati Lipid Research Clinic (LRC), indicated some heterogeneity. Whereas the sibling environmental effect (b) was the only source of heterogeneity between the two studies for TG, the correlation between marital environments (u) may also be considered as a source of heterogeneity for CH. Under parsimonious hypothesis, intergenerational differences in heritabilities were not found to be significant for either trait (y1 = y2 = z1 = z2 = 1). Maternal effects were significant for CH but not for TG. Correlations between marital environments (1 and u2) were not significant for TG, and may be considered nonsignificant for CH also under parsimonious hypotheses. In any case, the genetic (h2) and cultural (c2) heritabilities cannot be considered to be heterogeneous between the two studies. Based on pooled data, parsimonious hypothesis yields: h2 = .594 ± .041 and c2 = .035 ± .008 for CH, and h2 = .259 ± .034 and c2 = .108 ± .014 for TG.
UR - http://www.scopus.com/inward/record.url?scp=0020536356&partnerID=8YFLogxK
M3 - Article
C2 - 6859042
AN - SCOPUS:0020536356
SN - 0002-9297
VL - 35
SP - 468
EP - 483
JO - American journal of human genetics
JF - American journal of human genetics
IS - 3
ER -