TY - JOUR
T1 - Herpesvirus Infections and Risk of Parkinson's Disease
AU - Camacho-Soto, Alejandra
AU - Faust, Irene
AU - Racette, Brad A.
AU - Clifford, David B.
AU - Checkoway, Harvey
AU - Nielsen, Susan Searles
N1 - Funding Information:
This study was funded by WUSM Faculty Diversity Scholar Award (A.C.-S.), NIEHS K24ES017765 (B.A.R.), Michael J. Fox Foundation (B.A.R., S.S.N.), Paula C. and Rodger O. Riney Research Fund (B.A.R.), and the American Parkinson Disease Association (B.A.R., S.S.N.).
Publisher Copyright:
© 2020 S. Karger AG, Basel. Copyright: All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Introduction: Herpesviruses might play a role in the pathogenesis of neurodegenerative disorders. We sought to examine a possible association between alpha herpesvirus infections and Parkinson's disease. Methods: We conducted a population-based case-control study of incident Parkinson's disease in 2009 Medicare beneficiaries age 66-90 years (89,790 cases, 118,095 randomly selected comparable controls). We classified beneficiaries with any diagnosis code for "herpes simplex"and/or "herpes zoster"in the previous 5 years as having had the respective alpha herpesviruses. In beneficiaries with Part D prescription coverage, we also identified those prescribed anti-herpetic medications. We calculated odds ratios (OR) and 95% CI between alpha herpesvirus diagnosis/treatment and Parkinson's disease with logistic regression, with adjustment for age, sex, race/ethnicity, smoking, and use of medical care. Results: Parkinson's disease risk was inversely associated with herpes simplex (OR 0.79, 95% CI 0.74-0.84), herpes zoster (OR 0.88, 95% CI 0.85-0.91), and anti-herpetic medications (OR 0.87, 95% CI 0.80-0.96). Conclusion: Herpesvirus infection or treatment might reduce risk of Parkinson's disease, but future studies will be required to explore whether this inverse association is causal.
AB - Introduction: Herpesviruses might play a role in the pathogenesis of neurodegenerative disorders. We sought to examine a possible association between alpha herpesvirus infections and Parkinson's disease. Methods: We conducted a population-based case-control study of incident Parkinson's disease in 2009 Medicare beneficiaries age 66-90 years (89,790 cases, 118,095 randomly selected comparable controls). We classified beneficiaries with any diagnosis code for "herpes simplex"and/or "herpes zoster"in the previous 5 years as having had the respective alpha herpesviruses. In beneficiaries with Part D prescription coverage, we also identified those prescribed anti-herpetic medications. We calculated odds ratios (OR) and 95% CI between alpha herpesvirus diagnosis/treatment and Parkinson's disease with logistic regression, with adjustment for age, sex, race/ethnicity, smoking, and use of medical care. Results: Parkinson's disease risk was inversely associated with herpes simplex (OR 0.79, 95% CI 0.74-0.84), herpes zoster (OR 0.88, 95% CI 0.85-0.91), and anti-herpetic medications (OR 0.87, 95% CI 0.80-0.96). Conclusion: Herpesvirus infection or treatment might reduce risk of Parkinson's disease, but future studies will be required to explore whether this inverse association is causal.
KW - Herpesvirus
KW - Medicare
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=85099843948&partnerID=8YFLogxK
U2 - 10.1159/000512874
DO - 10.1159/000512874
M3 - Article
C2 - 33461199
AN - SCOPUS:85099843948
SN - 1660-2854
VL - 20
SP - 97
EP - 103
JO - Neurodegenerative Diseases
JF - Neurodegenerative Diseases
IS - 2-3
ER -