Herpes viral hepatitis in liver transplant recipients

J. Awad, M. G. Peters, E. Brunt, D. W. Hanto

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The incidence, treatment and outcome of histologically diagnosed herpes viral hepatitides were studied in 58 consecutive patients who received orthotopic liver transplants. Cytomegalovirus hepatitis occurred in 26% of patients, 75% of whom had a self-limited viral syndrome. Serum liver tests were not helpful in establishing the diagnosis. Liver culture and histology proved valuable in the diagnosis of herpes viral infections. Infection was more frequent in patients who received seropositive organs than in those who did not, but was not more common in those who required retransplantation. Two patients had Epstein Barr virus hepatitis and 1 had herpes simplex hepatitis. Prophylaxis for cytomegalovirus with acyclovir is important especially in those seronegative patients who receive seropositive organs.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalClinical Transplantation
Volume6
Issue number1
StatePublished - Jan 1 1992

Keywords

  • Hepatitis
  • Herpes virus
  • Transplantation

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    Awad, J., Peters, M. G., Brunt, E., & Hanto, D. W. (1992). Herpes viral hepatitis in liver transplant recipients. Clinical Transplantation, 6(1), 16-20.