Heritable Renal Phosphate Wasting Disorders

Marc K. Drezner, Michael P. Whyte

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Heritable disorders leading to renal Pi wasting may be the most common cause of rickets in developed countries. However, the molecular mechanisms underlying the biochemical abnormalities and deranged bone/cartilage mineralization in these diseases are complex, and our current models remain incomplete. Isolated renal Pi wasting and consequent low serum Pi concentrations characterize several genetic disorders that include: autosomal dominant hypophosphatemic rickets (ADHR), X-linked hypophosphatemia (XLH), and autosomal recessive hypophosphatemic rickets (ARHR). They share a key central pathogenic role for the endocrine molecule called fibroblast growth factor 23 (FGF23). Understanding the interrelationships between these gene mutations and regulation of FGF23 production and proteolysis has provided obvious as well as new and unanticipated therapeutic targets for management of this constellation of diseases. Currently, the investigational anti-FGF23 monoclonal antibody (KRN23), called burosumab, is showing favorable results in XLH. These advances have come from ground-breaking studies in humans and animal models that will fuel further successful investigation.

Original languageEnglish
Title of host publicationGenetics of Bone Biology and Skeletal Disease
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages761-782
Number of pages22
ISBN (Electronic)9780128041987
ISBN (Print)9780128041826
DOIs
StatePublished - Jan 1 2018

Keywords

  • Calcitriol
  • FGF-23
  • Hypophosphatemia
  • Inorganic phosphate
  • Osteomalacia
  • Phosphorus
  • Rickets
  • XLH

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    Drezner, M. K., & Whyte, M. P. (2018). Heritable Renal Phosphate Wasting Disorders. In Genetics of Bone Biology and Skeletal Disease: Second Edition (pp. 761-782). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804182-6.00040-X