Hereditary Colorectal Cancer Syndromes

Katerina Wells, Paul E. Wise

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Awareness of hereditary colorectal cancer syndromes is important to facilitate their identification because affected patients are at increased risk for early onset, synchronous, and metachronous colorectal malignancies, and certain extracolonic malignancies depending on the syndrome. Identification of an affected individual allows for screening and early interventions for patients and their at-risk kindred. Genetic counseling and testing is important to the care of these patients. As knowledge of the genetic basis of these syndromes grows, unique genotype-phenotype profiles allow clinicians to tailor surveillance and treatment strategies based on individual risk.

Original languageEnglish
Pages (from-to)605-625
Number of pages21
JournalSurgical Clinics of North America
Volume97
Issue number3
DOIs
StatePublished - Jun 2017

Keywords

  • Familial adenomatous polyposis
  • Hereditary nonpolyposis colorectal cancer
  • Inherited colon cancer
  • Lynch syndrome
  • MUTYH-associated polyposis
  • Serrated polyposis syndrome

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