her9 promotes floor plate development in zebrafish

Andrew J. Latimer, Jimann Shin, Bruce Appel

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Notochord, floor plate, and in anamniotes hypochord, are vertebrate embryonic midline structures that are the sources of molecules that pattern the nervous system, somites, and dorsal aorta. Midline precursor cells arise from the dorsal organizer during gastrulation, and Notch signaling is an important regulator of midline cell fate specification. To understand fully how Notch signaling regulates midline development, we investigated the role of potential Notch target genes. We show here that midline precursors express her9, a member of the hairy/Enhancer of split gene family. Although her9 inhibits notochord development and promotes floor plate specification, her9 expression in floor plate cells appears not to require Notch signaling. We show that, instead, her9 is a downstream effector of Nodal signaling for floor plate specification.

Original languageEnglish
Pages (from-to)1098-1104
Number of pages7
JournalDevelopmental Dynamics
Volume232
Issue number4
DOIs
StatePublished - Apr 2005

Keywords

  • Cyclops
  • Floor plate
  • Nodal
  • Notch
  • Zebrafish
  • her9

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