Hepatocellular progenitor cell tumor of the gallbladder: A case report and review of the literature

Indira Vadlamani, Elizabeth M. Brunt

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


A 75-year-old man presented to his physician with weakness, anorexia, and constant right upper quadrant pain. He underwent a laparoscopic cholecystectomy, which was converted to an open cholecystectomy due to presumed adhesions. Direct examination of the liver was negative for masses or lesions. A CT scan was negative for masses or nodules. The gallbladder was 8.5 × 2.5cm 2, with a diffusely thick wall measuring 2.5cm. Microscopic examination showed a monomorphic tumor consisting of cells with increased nuclearcytoplasmic ratio and occasional nucleoli, infiltrating the entire gallbladder uniformly. The tumor cells that reacted to antibodies directed against HepPar1 , CAM 5.2, CK19 and scattered cells were immunoreactive for CD117, CD34, and CD56. This immunohistochemical profile suggested a 'hepatocellular progenitor cell tumor of the gall bladder'. This report is, to our knowledge, the first such case of a tumor of this cell type reported in the gallbladder. In addition, we present a review of the literature.

Original languageEnglish
Pages (from-to)864-870
Number of pages7
JournalModern Pathology
Issue number6
StatePublished - Jun 2005


  • Gallbladder tumor
  • Hepatic progenitor cells
  • Immunohistochemistry


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