TY - JOUR
T1 - Hepatocellular progenitor cell tumor of the gallbladder
T2 - A case report and review of the literature
AU - Vadlamani, Indira
AU - Brunt, Elizabeth M.
PY - 2005/6
Y1 - 2005/6
N2 - A 75-year-old man presented to his physician with weakness, anorexia, and constant right upper quadrant pain. He underwent a laparoscopic cholecystectomy, which was converted to an open cholecystectomy due to presumed adhesions. Direct examination of the liver was negative for masses or lesions. A CT scan was negative for masses or nodules. The gallbladder was 8.5 × 2.5cm 2, with a diffusely thick wall measuring 2.5cm. Microscopic examination showed a monomorphic tumor consisting of cells with increased nuclearcytoplasmic ratio and occasional nucleoli, infiltrating the entire gallbladder uniformly. The tumor cells that reacted to antibodies directed against HepPar1 , CAM 5.2, CK19 and scattered cells were immunoreactive for CD117, CD34, and CD56. This immunohistochemical profile suggested a 'hepatocellular progenitor cell tumor of the gall bladder'. This report is, to our knowledge, the first such case of a tumor of this cell type reported in the gallbladder. In addition, we present a review of the literature.
AB - A 75-year-old man presented to his physician with weakness, anorexia, and constant right upper quadrant pain. He underwent a laparoscopic cholecystectomy, which was converted to an open cholecystectomy due to presumed adhesions. Direct examination of the liver was negative for masses or lesions. A CT scan was negative for masses or nodules. The gallbladder was 8.5 × 2.5cm 2, with a diffusely thick wall measuring 2.5cm. Microscopic examination showed a monomorphic tumor consisting of cells with increased nuclearcytoplasmic ratio and occasional nucleoli, infiltrating the entire gallbladder uniformly. The tumor cells that reacted to antibodies directed against HepPar1 , CAM 5.2, CK19 and scattered cells were immunoreactive for CD117, CD34, and CD56. This immunohistochemical profile suggested a 'hepatocellular progenitor cell tumor of the gall bladder'. This report is, to our knowledge, the first such case of a tumor of this cell type reported in the gallbladder. In addition, we present a review of the literature.
KW - Gallbladder tumor
KW - Hepatic progenitor cells
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=20344379693&partnerID=8YFLogxK
U2 - 10.1038/modpathol.3800367
DO - 10.1038/modpathol.3800367
M3 - Review article
C2 - 15696116
AN - SCOPUS:20344379693
SN - 0893-3952
VL - 18
SP - 864
EP - 870
JO - Modern Pathology
JF - Modern Pathology
IS - 6
ER -