TY - JOUR
T1 - Hepatocellular carcinoma
T2 - Predisposing conditions and precursor lesions
AU - Bailey, Marie Ann
AU - Brunt, Elizabeth M.
PY - 2002/7/23
Y1 - 2002/7/23
N2 - The global incidence of HCC is rising; in the United States, its rise is in parallel to that of cirrhosis due to the HCV and obesity epidemics. The lack of adequate treatment for advanced HCC mandates both prevention and early detection of these lesions. The limitations of currently available histopathologic evaluations, serologic markers, and radiographic imaging modalities in detecting HCC and its precursors have been outlined in this review. Refinements of all of these may lead to better HCC detection, earlier intervention, and successful treatment. Randomized controlled trials are necessary to evaluate the most efficacious and cost-effective approach to screening.
AB - The global incidence of HCC is rising; in the United States, its rise is in parallel to that of cirrhosis due to the HCV and obesity epidemics. The lack of adequate treatment for advanced HCC mandates both prevention and early detection of these lesions. The limitations of currently available histopathologic evaluations, serologic markers, and radiographic imaging modalities in detecting HCC and its precursors have been outlined in this review. Refinements of all of these may lead to better HCC detection, earlier intervention, and successful treatment. Randomized controlled trials are necessary to evaluate the most efficacious and cost-effective approach to screening.
UR - http://www.scopus.com/inward/record.url?scp=0035992198&partnerID=8YFLogxK
U2 - 10.1016/S0889-8553(02)00017-1
DO - 10.1016/S0889-8553(02)00017-1
M3 - Review article
C2 - 12134622
AN - SCOPUS:0035992198
SN - 0889-8553
VL - 31
SP - 641
EP - 662
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 2
ER -